郑州大学学报（医学版）2012，Vol.47Issue(6)：830-832,3.DOI:10.3969/j.issn.1671-6825.2012.06.025
血清胱抑素C检测在造影剂肾病早期诊断中的价值
Value of serum cystatin C in early diagnosis of contrast induced nephropathy
赵瑛瑛 1欧阳军 2王建生 1张宛哲 1张文吉 1孟晶茜 1申鹏霄 1刘丁 1汤建民3
作者信息
- 1. 郑州大学第二附属医院肾内科,郑州,450014
- 2. 河南省医药科学研究院,郑州,450052
- 3. 郑州大学第二附属医院心血管内科,郑州,450014
- 折叠
摘要
Abstract
Aim:To study the value of detecting serum cystatin C( Cys-C ) in early diagnosis of contrast induced ne-phropathy( CIN ). Methods:Taking retrospective analysis method,a total of 427 patients undergoing diagnostic coronary angiography or percutaneous coronary intervention were enrolled. Serum Cys-C, serum creatinine( Scr ) and other relevant clinical data of the patients were collected before imaging and 24 hours,48 hours after imaging. Two methods were used to diagnose CIN. A:detecting the level of Scr; B: detecting the level of serum Cys-C. The specificity and sensitivity of the above two methods were analyzed respectively. Results: Compared with that before imaging[ ( 1. 03 ±0.18 )mg/L ], the serum Cys-C increased significantly at 24 hours[ ( 1.27 ±0.21 )mg/L ] and 48 hours[ ( 1.31 ±0.26 )mg/L ] after imaging( F = 39.542, P =0.031 ). By method A,the incidence of CIN were 6. 57% at 24 hours after imaging and 7. 20% at 48 hours after imaging,which were lower than those by method B( 10. 17% and 10.81% ,x2 =262.359 and 236. 669 ,P <0.001 ). By method B,the specificity and sensitivity of diagnosing CIN were 96.77% and 95.92% at 24 hours after imaging,91. 18% and 95. 43% at 48 hours after imaging. Conclusion :The level of serum Cys-C could be a sensitive marker to diagnose CIN in early stage. B关键词
胱抑素C/冠状动脉造影术/造影剂肾病Key words
cystatin C/ coronary angiography/ contrast induced nephropathy分类
医药卫生引用本文复制引用
赵瑛瑛,欧阳军,王建生,张宛哲,张文吉,孟晶茜,申鹏霄,刘丁,汤建民..血清胱抑素C检测在造影剂肾病早期诊断中的价值[J].郑州大学学报（医学版）,2012,47(6):830-832,3.
