郑州大学学报（医学版）2012，Vol.47Issue(6)：836-839,4.DOI:10.3969/j.issn.1671-6825.2012.06.027
NF-κB阻滞剂PDTC在冠脉搭桥术中对心肌的保护效果
Effects of NF-κB retardant PDTC on myocardium during coronary artery bypass grafting
张竞超 1牛冬林 1赵文增 1苗岩1
作者信息
- 1. 郑州大学第一附属医院心血管外科,郑州,450052
- 折叠
摘要
Abstract
Aim:To observe the protective effect of the NF-kB retardant on myocardium during coronary artery bypass grafting( CABG ). Methods:A total of 20 patients undergoing CABG were allocated into two groups. Group A was given cold crystal cardioplegia containing the NF-kB retardant PDTC, and group B used the ordinary cold crystal cardioplegia. The 2 groups were given the same narcosis and operation way. Before the operation,during the operation,1 h and 24 h after the operation,the serum levels of creatine kinase( CK-MB ),myocardium troponin( cTnI ) and lactic dehydrogenase( LDH ) were determined. Results:There were no statistic differences in the indexes mentioned above between the 2 groups before the op-eration( P > 0. 05 ). The levels of CK-MB, cTnI and LDH of the 2 groups were higher during the operation, 1 h and 24 h after the operation than before the operation,but those of group A were lower than group B( F_group = 121. 003 ,32. 326 and 250.088;F_time =53.802,51.574 and 227.901;P <0.05 ). Conclusion: The NF-kB retardant could reduce the injury to myocardium during CABG.关键词
心肌保护/NF-κB/吡咯烷二硫代氨基甲酸钠/心肌酶Key words
myocardium protection/ NF-KB /aminodithioformic acid/myocardial enzyme分类
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张竞超,牛冬林,赵文增,苗岩..NF-κB阻滞剂PDTC在冠脉搭桥术中对心肌的保护效果[J].郑州大学学报（医学版）,2012,47(6):836-839,4.
