核化学与放射化学2013，Vol.35Issue(1)：40-45,6.DOI:10.7538/hhx.2013.35.01.0040
新型Aβ斑块显像剂18F-W372
A Novel Aβ-Amyloid Imaging Agent 18 F-W372 for Alzheimer's Disease
摘要
Abstract
A new Aβ-amyloid imaging agent 7-methoxy-2 (6-fluoropyridin-3-yl) imidazo[2, l-b]-8-pyridinothiazol (18F-W372) is synthesized, the non-decay corrected radiochemical yield is (25. 3 + 7. 1)% (n = 6), the radiochemical purity is more than 99.5%, and the specific activity is 659-721 PBq/mol. Biodistribution of the 18F-W372 in mice indicates that uptake is high in brain, the brain is (4. 36 + 1. 44)%ID/g at 5 min, the washout from normal brain is fast, and the brain is (0. 54±0. 16)%ID/g at 30 min post injection. The acute toxici-ty test of 18F-W372 proves its safety in clinical use. The cortical/cerebellar specific uptake is higher in AD patients than in controls at 40 min after injection of 18F-W372. 18F-W372 may have potential as a Aβ-amyloid imaging agent for Alzheimer's disease.关键词
Aβ斑块显像剂/18F-W372/小鼠体内分布Key words
Aβ-amyloid imaging agent/ 18F-W372/ biodistribution in mice分类
医药卫生引用本文复制引用
张晓军,富丽萍,张锦明,李云刚,田嘉禾..新型Aβ斑块显像剂18F-W372[J].核化学与放射化学,2013,35(1):40-45,6.基金项目
国家自然科学基金资助项目(30670586) （30670586）
