湖南大学学报（自然科学版）2012，Vol.39Issue(9)：62-66,5.
新型脱碳木脂素类化合物合成方法与肿瘤抑制活性研究
Study on Synthesis and Anticancer Activities of New Norlignans Derivatives
摘要
Abstract
In this study, we have synthesized a series of new norlignan compounds 2a~2g and evaluated their anticancer activities with MTT assay by using human hepaioma Bel-7402 cells, human breast ade-nocarcinoma MCF-7 cells, human lung carcinoma A549 cells and human cervical carcinoma HeLa cells. It has been shown that the products (2a-2g) exhibit higher cytotoxicity to cells, and especially, product 2b treated with Bel-7402 cells shows a lower cytotoxicity (IC50: 18. 9μg/mL) than free paclitaxel.关键词
脱碳木脂素/催化二聚/肿瘤抑制活性/合成Key words
norlignans/ catalytic dimerization/ anticancer activities/ synthesis分类
化学化工引用本文复制引用
向建南,刘开建,李君姊,梁志武..新型脱碳木脂素类化合物合成方法与肿瘤抑制活性研究[J].湖南大学学报（自然科学版）,2012,39(9):62-66,5.基金项目
湖南省自然科学基金资助项目(11JJ5008) （11JJ5008）
