湖南中医药大学学报2012，Vol.32Issue(12)：58-60,3.DOI:10.3969/j.issn.1674-070X.2012.12.030.058.03
妇科千金片对盆腔炎大鼠子宫、卵巢、输卵管Caspase-3表达的影响
The influence of Qianjintablet to mouse's Caspase-3 expression of uterus/ovary/uterine tube with pelvic inflammatory disease
摘要
Abstract
Objective To research the mechanism of Qianjintablet to treat pelvic inflammatory disease. Methods Selects female Wistar mousse, makes acute pelvic inflammatory disease model by vaccinating mixed bacterial liquid of escherichia coli,staphylococcus aureus,ureaplasma urealyticum in uterus. After making model successfully,experimental mouse were randomly divided into the blank group, the shamoperation group, the model group, the low dosage group of Qianjintablet, the middle dosage group of Qianjintablet, the high dosage group of Qianjintablet, Fuyankang group, the Roxithromycin group, after drug treatment,takes mouse' s tissues like uterus,uterine tube,ovary,etc, observes caspases-3's expression of mouse' s tissues like uterus,uterine tube,ovary,etc by immunohistochemisty. Results Compared with the blank group and the shamoperation group, the model group's caspase-3 gray threshold of mouse' s tissues like uterus,uterine tube, ovary all reduced, the difference has statistical significance(P<0.05);Compared with the model group, the low dosage group of Qianjintablet, the middle dosage group of Qianjintablet, the high dosage group of Qianjintablet, Fuyankang group, the Roxithromycin group' s caspase3 gray threshold of mouse' s tissues like uterus.uterine tube, ovary all increased, and the difference has statistical significance(P<0.05);Compared with the low dosage group of Qianjintablet, the middle dosage group of Qianjintablet, the high dosage group of Qianjintablet, Fuyankang group, the Roxithromycin group' s caspase3 gray threshold of mouse' s tissues like uterus,uterine tube, ovary all increased,and the difference has statistical significance(P<0.05). Conclusion Qianjintablet can increase caspase3 gray threshold,and that reducing caspase-3's positive cells number may be one of the mechanism to cure Pelvic inflammatory disease.关键词
妇科千金片/盆腔炎/半胱氨酸天冬氨酸特异性蛋白酶3Key words
Qianjintablet/ Pelvic inflammatory disease/ Caspase-3分类
医药卫生引用本文复制引用
袁建菱,郭建生,左之文,曾贵荣,张国民,丁志高..妇科千金片对盆腔炎大鼠子宫、卵巢、输卵管Caspase-3表达的影响[J].湖南中医药大学学报,2012,32(12):58-60,3.基金项目
湖南省高校创新平台开放基金项目(10K045).湖南省普通高校中药现代化研究重点实验室资助. （10K045）
