华西口腔医学杂志2012，Vol.30Issue(6)：628-631,4.DOI:10.3969/j.issn.1000-1182.2012.06.016
内皮细胞型一氧化氮合成酶Glu298Asp基因多态性与牙周炎伴Ⅱ型糖尿病的相关性研究
Relationship between endothelial nitric oxide synthase Glu298Asp gene polymorphisms and the chronic periodontitis with type 2 diabetes mellitus
摘要
Abstract
Objective To study the relationship between endothelial nitric oxide synthase (eNOS) Glu298Asp gene polymorphism and chronic periodontitis (CP) with type 2 diabetes mellitus (T2DM). Methods DNA from patients' buc-cal swabs of CP, CP with T2DM, T2DM and health was isolated and extracted. The eNOS Glu298Asp gene polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) respectively. Results The distribution of eNOS Glu298Asp genotype in CP group, T2DM group, CP with T2DM group and health group showed statistical differences (x2=18.503, P=0.005), and the gene frequency showed statistical differences (x2= 8.243, P=0.041). Compared health group to CP with T2DM group, OR value of the genetype T was 0.962, 95% confidence interval lay in between 0.737 to 1.256, which showed T maybe a protective factor. While OR value of the genetype G was 1.043, 95% confidence interval lay in between 0.781 to 1.391, which showed G maybe a risk factor. However, neither T nor G was statistically significant. Conclusion Based on these findings, there are some association between eNOS Glu298Asp polymorphism and the risk of CP group, T2DM group, CP with T2DM group.关键词
慢性牙周炎/Ⅱ型糖尿病/一氧化氮合成酶/基因多态性Key words
chronic periodontitis/ type 2 diabetes mellitus/ nitric oxide synthase/ gene polymorphism分类
生物科学引用本文复制引用
侯海娟,张帆,赵美林,曹桂芬,黄海云,黄萍..内皮细胞型一氧化氮合成酶Glu298Asp基因多态性与牙周炎伴Ⅱ型糖尿病的相关性研究[J].华西口腔医学杂志,2012,30(6):628-631,4.基金项目
"十一五"国家科技攻关计划基金资助项目(2007BAI18B02) （2007BAI18B02）
