四川大学学报（医学版）2013，Vol.44Issue(1)：42-45,4.
炎症细胞因子诱导Tca8113细胞表达PD-L1的作用研究
Inflammatory Factors Promote the Expression of PD-L1 in Tca8113
摘要
Abstract
Objective To investigate the mechanism of immunologic escape in the tumor microenvironment, study the expression of programmed death 1 ligand-1 (PD-L1) in Tca8113 with treatment of inflammatory factors. Methods The expression of PD-L1 treated with inflammatory factors (IL-lβ, IL-2, IL-6, TNF-α, IFN-γ) was detected by flow cytometry (FCM). Results The expression of PD-L1 in Tca8113 was up-regulated conspicuously with treatment of inflammatory factors (P<0. 05), including: IL-1β, IL-6, TNF-α ,IFN-γ. And the factors played the role in synergistic effects, most significantly in the groups of IL-1β+ IFN-γ, TNF-α+IFN-γ and IL-lβ+IL-6 + IFN-γ+TNF-α. But the influence of IL-2 on the expression of PD-L1 was not significant (P>0. 05). Conclusion With the up-regulated expression of PD-L1, the tumor would be escaped more easily from the immunoreactions, while there were an abundance of inflammatory factors in the tumor microenvironment.关键词
炎症细胞因子/程序性死亡因子配体-1/Tca8113Key words
Inflammatory factors/PD-L1/Tca8113引用本文复制引用
卢礼兵,陈娇,冯云,周陈晨,张平..炎症细胞因子诱导Tca8113细胞表达PD-L1的作用研究[J].四川大学学报（医学版）,2013,44(1):42-45,4.基金项目
国家自然科学基金(No.30972764)资助 （No.30972764）
