基础医学与临床2013，Vol.33Issue(1)：93-97,5.
LATS2基因在上皮性卵巢癌中的表达和临床意义
The expression and clinical significance of LATS2 in epithelial ovarian cancer
雷静 1万霖 1李惠新2
作者信息
- 1. 兰州大学第二临床医学院,甘肃兰州730000
- 2. 兰州大学第二医院妇科,甘肃兰州730000
- 折叠
摘要
Abstract
Objective To detect the expression of large tumor suppressor homolog 2 ( LATS2) in human epithelial ovarian cancer tissue and its correlation with tumor progression. Methods RT-PCR, SYBR RT-PCR and Immuno-histochemistry were employed to detect the expression of LATS2 mRNA and protein. Results The expression of LATS2 mRNA in epithelial ovarian cancer was significant lower than that in benign,and normal group(P 〈0. 01) , and there are obvious connection between stage and metastasis of lymph node ( P 〈 0. 05). The LATS2 was mainly located in cytolymph. The expression of LATS2 protein in epithelial ovarian cancer group was significant lower than that in the other groups(P 〈0. 01). The same results were obtuired in different stage and metastasis of lymph node. Conclusions LATS2 may play a role in the tumorigenesis of epithelial Ovarian cancer. It maybe has certain progression for early diagnosis and forecast of ovarian cancer.关键词
LATS2/上皮性卵巢癌/SYBR Green/免疫组化Key words
LATS2/ epithelial ovarian cancer/ SYBR Green/ immunohistochemistry分类
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雷静,万霖,李惠新..LATS2基因在上皮性卵巢癌中的表达和临床意义[J].基础医学与临床,2013,33(1):93-97,5.
