激光生物学报2012，Vol.21Issue(5)：406-411,6.DOI:10.3969/j.issn.1007-7146.2012.05.005
P38α/β在黑色素瘤细胞辐射应急响应中的作用
The Role of P38α/β in Acute Response of Uveal Melanoma Cells Exposed to Ionizing Radiation
摘要
Abstract
The function of P38 mitogen-activated protein kinase ( MAPK ) pathway in tumor initiation and promotion is still controversial. In the study, cell proliferation rate of human uveal melanoma cell lines 92-1 and OCM-1 was significantly reduced and micronucleus induction was also markedly suppressed by P38α/β specific inhibitor SB202190 regardless of X-ray irradiation or not. However, impact on γH2AX foci and cloning efficiency were barely observed. These results imply that P38MAPK might play a role in the malignant development of melanoma through promoting cell proliferation and enhancing genomic instability instead of modifying DNA damage repair and radioresistance.关键词
P38MAPK/黑色素瘤/辐射敏感性/基因组不稳定性Key words
P38MAPK/ melanoma/ radiosensitivity/ genomic instability分类
生物科学引用本文复制引用
李君红,叶才勇,王菊芳,周光明..P38α/β在黑色素瘤细胞辐射应急响应中的作用[J].激光生物学报,2012,21(5):406-411,6.基金项目
国家重点基础研究发展计划(973计划)项目(2010CB834201) （973计划）
中国科学院百人计划资助项目(O760140BRO) （O760140BRO）
国家自然科学基金资助项目(10979062) （10979062）
