激光生物学报2012，Vol.21Issue(6)：569-574,6.DOI:10.3969/j.issn.1007-7146.2012.06.017
从红树植物中筛选具有抗菌、抗氧化和抗肿瘤活性的内生真菌
Screening of Endophytic Fungi with Antibacterial,Antioxidant and Antitumor Activities from Mangrove Plants
摘要
Abstract
25 strains endophytic fungi were isolated from mangrove plants Sonneratia apetala, Sesuvium portulacastrum and Kandelia candel. Using the filter paper disc agar diffusion method, the radical scavenging methods ( DPPH,·OH and ABTS+ ) and MTT assay, the antibacterial, antioxidant and antitumor activities of the ethyl acetate extracts of the fermentation broths were studied. As a result, 12 strains showed antibacterial activity to one tested bacterium at least, accounting for 48% of the total tested strains. 3 ,12 and 8 strains showed strong radical scavenging activities ( 0 mg/mL < EC50≤1 mg/mL ) to DPPH radical,·OH radical and ABTS+ radical, respectively. 8 strains showed significant inhibition against HepG2 tumor cells or HeLa tumor cells. The result indicated that the endophytic fungi from mangrove plants were important resources which produce rich antibacterial, antioxidant and antitumor substances.关键词
红树植物/内生真菌/抗菌/抗氧化/抗肿瘤Key words
mangrove plants/ endophytic fungi/ antibacterial/ antioxidant/ antitumor分类
生物科学引用本文复制引用
刘伟,倪辉,黄高凌,杨远帆,李利君,杜希萍..从红树植物中筛选具有抗菌、抗氧化和抗肿瘤活性的内生真菌[J].激光生物学报,2012,21(6):569-574,6.基金项目
集美大学博士启动基金项目 (ZQ2011004) （ZQ2011004）
福建省自然科学基金项目(2012J05058) （2012J05058）
李尚大集美大学学科建设基金(ZC2012006) （ZC2012006）
