军事医学2012，Vol.36Issue(12)：925-928,4.
氟氯氰菊酯亚急性吸入毒性实验研究
Inhalation toxicity of cyfluthrin for 28-day repeated dose in rats
摘要
Abstract
Objective To determine the inhalation toxicity and find the non -observed adverse effect level (NOAEL) of cyfluthrin for a 28-day repeated dose in rats. Methods Clean-grade SD rats were randomly divided into 5 groups with 5 females and 5 males in each. The animals inhaled DMSO or cyfluthrin at the concentration of 0, 7. 81 , 9. 05 and 18. 98 mg/m for 4 weeks (6 h/d, 5 d/w). At the end of inhalation , all the animals were kindly sacrificed. Their organs were collected for histopathological examination . Blood samples were collected for analysis of complete blood count , biochemistry and coagulation. Results The animals in 18. 98 mg/m3 group were found scratching repeatedly around the mouth, listless, fidgeting, trembling, discharging blood around the mouth and nose . However, symptoms in females were less serious than in males. Furthermore , the body mass , feed efficiency , weight of kidney of animals in this dose male group were found decreased compared with the control group . Biochemistry detection revealed that serum AST was elevated markedly in both genders of 18. 98 mg/m3 group and in males of 9. 05 mg/m3 group. No obvious abnormity was found in 7.81 mg/m3 group or control group. Conclusion Based on the results above, the non-observed adverse effect level (NOAEL) of cyfluthrin in SD rats is 7. 81 mg/m3 for 28 d repeated inhalation in this study.关键词
氟氯氰菊酯/拟除虫菊酯/吸入/中毒Key words
cyfluthrin/ pyrethroid/ inhalation / poisoning分类
农业科技引用本文复制引用
秦珩,乔善磊,顾军,钟义红,杨洪宝,王玉邦,施爱民..氟氯氰菊酯亚急性吸入毒性实验研究[J].军事医学,2012,36(12):925-928,4.基金项目
江苏高校优势学科建设工程资助项目 （）
