昆明医科大学学报2012，Vol.33Issue(12)：30-32,3.
氯胺酮对神经病理性疼痛大鼠的影响
Effects of Ketamine on Rats with Neuropathic Pain
摘要
Abstract
Objective To investigate the effect of ketamine on spinal nerve ligation (SNL) induced neuropathic pain in rats. Methods 24 healthy adult SD rats weight 160-200g were randomly divided into 3 group (n = 8) ; sham operation group (S) , SNL group (C) and ketamine group (K). In group (S) , the spinal nerve were exposed but not ligated in other groups, the spinal nerve were ligated. From the the third day after operation, 10 mg/kg ketamine were injected intraperitioneally in group K, the same volume normal saline was injected intraperitoneally respective in group C and S . The themal pain threshold were measured at the today before operation and 3d, 5d, 7d, 14d after operation. Results Compared with group S, the PWL in group C and group K were significantly reduced. Compared with group C, the PWL after operation 5 d, 7 d, 14 d were increased significantly (P<0.05). Conclusion Intraperitoneal administration of ketamine can alleviate the neuralgia in rats.关键词
神经病理性疼痛/氯胺酮/大鼠Key words
Neuropathic pain:Ketamine:Rat分类
医药卫生引用本文复制引用
王慧明,麻伟青..氯胺酮对神经病理性疼痛大鼠的影响[J].昆明医科大学学报,2012,33(12):30-32,3.基金项目
云南省应用基础研究基金资助项目(2011FZ319) （2011FZ319）
