昆明医科大学学报2012，Vol.33Issue(12)：55-60,6.
T-cadherin和LMP-1在鼻咽癌中的表达及相关性研究
Expression and Correlation of T-cadherin and LMP-1 in Nasopharyngeal Carcinoma
摘要
Abstract
Objective To research the expression of T-cadherin and LMP-1 in nasopharyngeal carcinoma (NPC) , investigate the correlation between them and the relationship between abnormal expression of T-cadherin gene and the clinicopathological characteristics of nasopharyngeal carcinoma. Methods Expression of T-cadherin and LMP-1 in 50 NPCs and 20 nasopharyngitis tissues was detected by SP immunohistochemical method. The relationship between T-cadherin differential expression and clinical pathological factors in nasopharyngeal carcinoma was analyzed. Results In NPC and nasopharyngitis tissue, the positive expression rates of T-cadherin were 40% and 100% (P<0.01) , and those of LMP-1 were 64% and 20% (P<0.0l) respectively. Spearman correlation analysis showed that the expression of T-cadherin and LMP-1 was negatively correlated in NPC. The expression of T-cadherin in NPC was correlated with TNM stage and lymph node metastasis. T-cadherin expression had no significant correlation with age, gender and tumor diameter. Conclusion T-cadherin expression in NPC is significantly lower and negatively correlated with LMP-1 expression, suggesting the abnormal expression of T-cadherin and LMP-1 in NPC may play an important role in the initiation, progression and metastasis of NPC.关键词
T-cadherin/鼻咽癌/LMP-1/免疫组织化学Key words
T-cadherin:Nasopharyngeal carcinoma:LMP-1:Immunohistochemistry分类
医药卫生引用本文复制引用
董超,任艳鑫,杨润祥,庄莉,任宏轩..T-cadherin和LMP-1在鼻咽癌中的表达及相关性研究[J].昆明医科大学学报,2012,33(12):55-60,6.基金项目
云南省教育厅科学研究基金资助项目(09Y0172) （09Y0172）
