昆明医科大学学报2012，Vol.33Issue(12)：102-106,5.
代谢综合征患者胰岛素抵抗与血浆醛固酮相关性研究
The Relationship of Plasma Aldosterone and Insulin Resistance in Patients with Metabolic Syndrome
丘红梅 1沈国清 1刘开平 1李薇 1周晓芳 1姚纪瑜1
作者信息
- 1. 昆明医科大学第六附属医院内分泌科,云南玉溪653100
- 折叠
摘要
Abstract
Objective To analyse the relationship of plasma aldosterone and insulin resistance and its components in patients with the metabolic syndrome (MS).Methods 79 metabolic syndrome patients were divided into three groups according to the different components of MS: 31 patients with type 2 diabetes mellitus and hypertension ( MS1 group) , 28 patients with type 2 diabetes mellitus ( MS2 group) and 20 patients with hypertension ( MS3 group). 20 normal subjects served as controls. All patients were given 3 h oral glucose tolerance test and orizontal and vertical position of aldosterone test, HOMA-insulin resistance index (HOMA-IR) was calculated by Homeostasis Model. Results Plasma aldosterone, the insulin area under curve (INSAUC) , HOMA-IR and prevalence of insulin resistance were significantly higher in the clustering of MS components than control group (P< 0.05). These indexes were significantly higher in MSI than MS2 and MS3 group in the clustering of MS components (P<0.05). These indexes were higher in MS2 group than in MS3 group, but there was no significant difference (P >0.05). Pearson correlation analysis showed that plasma aldosterone was positively correlated with body mass index (BMI) , waist circumference (WC) , triglyceride (TG) , fasting plasma glucose (FPG) , fasting insulin (FINS), HOMA-IR and diastolic blood pressure (DBP) (r = 0.562, P<0.01; r = 0.502, P<0.01; r=0.394, P<0.01; r=0.225, P<0.01; r=0.586, P<0.01; r=0.385 , P<0.01; r = 0.299, P<0.0l), negatively correlated with high density lipoprotein cholesterol (HDL-C) (r = -0.298, P<0.01). The multiple regression analysis showed that HOMA-IR was an independent factor of plasma aldosterone level in patients with the metabolic syndrome ( β =0.12, F<0.05). Conclusion The increasing of plasma aldosterone in patients with the metabolic syndrome may be related with IHOMA-IR and some components of MS.关键词
代谢综合征/胰岛素抵抗/醛固酮Key words
Metabolic: syndrome:Insulin resistance:Aldosterone分类
医药卫生引用本文复制引用
丘红梅,沈国清,刘开平,李薇,周晓芳,姚纪瑜..代谢综合征患者胰岛素抵抗与血浆醛固酮相关性研究[J].昆明医科大学学报,2012,33(12):102-106,5.
