临床与实验病理学杂志2012，Vol.28Issue(12)：1342-1345,4.
多房囊性肾细胞癌7例临床病理分析
Multilocular cystic renal cell carcinoma: a clinicopathological analysis of 7 cases
方三高 1江军 2刘才宝 3马强 1林俐 1肖华亮1
作者信息
- 1. 第三军医大学大坪医院野战外科研究所病理科,重庆,400042
- 2. 第三军医大学大坪医院野战外科研究所泌尿外科,重庆,400042
- 3. 第三军医大学大坪医院野战外科研究所影像中心,重庆,400042
- 折叠
摘要
Abstract
Purpose To explore the clinicopathological features, diagnosis and differential diagnosis of multilocular cystic renal cell carcinoma ( MCRCC ). Methods Seven cases of MCRCC were reported by light microscopy and immunohistochemical study with review of related literatures. Results All patients were adults ( six males and one female ) and their ages ranged from 29 to 75 years ( mean, 52 years ). Ultrasonogram ( US ) and/or CT revealed a well-demarcated multicystic mass without expansile solid nodules in the thin septa. Grossly, the cut surface of the tumor showed small and large cysts which were filled with serous or hemorrhagic fluid and separated the tumor from the kidney by fibrous pseudocapsule. Microscopically, the cyst walls of tumors were often devoid of epithelium or occasionally covered with a few layers of clear cells showing Fuhrman grade 1 nuclear features with less mitotic activity. Meanwhile, no coagulative necrosis but proteinaceous components were found in all cases. Sometimes, the septa contained aggregates of epithelial cells with transparent cytoplasm. Thus, these characteristics of morphology strongly suggested as a diagnostic clue. Immunohistochemi-cally, the clear cell was positive for CD10, CK and vimentin, but negative for CD68. Conclusion MCRCC is a rare histological subtype of renal cell carcinoma with more favorable prognosis. It should be distinguished from some mimics such as clear cell renal cell carcinoma with cystic change and cystic nephroma.关键词
肾脏肿瘤/多房囊性肾细胞癌/临床病理/免疫组织化学/鉴别诊断Key words
kindey neoplasms/ multilocular cystic renal cell carcinoma/ clinical pathology/ immunohistochemistry/ differential diagnosis分类
医药卫生引用本文复制引用
方三高,江军,刘才宝,马强,林俐,肖华亮..多房囊性肾细胞癌7例临床病理分析[J].临床与实验病理学杂志,2012,28(12):1342-1345,4.
