临床与实验病理学杂志2012，Vol.28Issue(12)：1356-1360,5.
维吾尔族妇女子宫颈癌HPV16感染与TGF/Smads信号通路相关蛋白表达的关系
Correlation between human papillomavirus type 16 infection and protein of TGF/Smads signal pathway expression in cervical cancers of Uighur women
摘要
Abstract
Purpose To explore the relationship between human papillomavirus ( HPV16 ) infection and expression of TGF/Smads signal pathway protein TGF-βl, Smad4, Runx3 in cervical cancer of Uighur women, and to investigate their effect on cervical cancer progression. Methods In situ hybridization and immunohistochemistry were performed to detect the expression of HPV16 and TGF-β1, Smad4, Runx3 protein in formalin-fixed and paraffin-embeded cervical tissue specimens from Uighur women with cervicitis, cervical in-traepithelial neoplasia ( CIN ) and cervical squamous cell carcinoma. Results The positive expression rates of HPV16, TGF-β1 in chronic cervicitis, CIN and cervical cancer were 8% , 47. 62% , 62. 22% and 0, 41. 26% , 71. 11% , respectively. The expression of HPV16 and TGF-β1 was higher in CIN and cervical cancer than in chronical cervicitis ( P < 0. 05 ). The expression of HPV16 and TGF-βl was related to the FIGO stage. TGF-βl expression was found in both cytoplasm and extracellular stroma, increased when the pathologic grade was getting worse and when the lymphnode had metastasis. The positive expression rates of Smad4 and Runx3 in chronic cervicitis, CIN and cervical cancer were 80% , 69. 84% , 40% and 84% , 69. 84% , 44. 44% , respectively( P <0. 05 ). Runx3 was related to lymph node metastasis. In cervical cancer there was positive correlation between HPV16 and TGF-β1 ( r =0. 515, P < 0. 001 ), Smad4 and Runx3 also had positive correlation in cervical cancer( r = 0. 329, P < 0. 027 ), but a negative correlation was found between TGF-β1 with Runx3 ( r = -0. 318, P <0. 033 ). Conclusions The changes in the expression of TGF-β1, Smad4 and Runx3 in cervical lesions might be related to the pathogenesis and progression of CIN and cervical cancer in Uighur women, and HPV16 infection may be a trigger factor affecting the molecular signal pathway.关键词
子宫颈肿瘤/人乳头状瘤病毒16/TGF/Smads信号通路Key words
uterine cervical neoplasms/ human papillomavirus 16/ TGF/Smads signal pathway分类
医药卫生引用本文复制引用
李巧稚,塔拉甫·托坎,卡德尔江·木沙,高哈尔·阿依弹..维吾尔族妇女子宫颈癌HPV16感染与TGF/Smads信号通路相关蛋白表达的关系[J].临床与实验病理学杂志,2012,28(12):1356-1360,5.基金项目
新疆自然科学青年基金(2012211B10) （2012211B10）
