大肠癌中SDF-1与CXCR4的表达及临床意义OA北大核心CSCDCSTPCD
Expression of SDF-1 and its receptor CXCR4 in colorectal adenocarcinoma and their clinical significances
目的 观察基质细胞衍生因子1(stromal cell-derived factor 1,SDF-1)及其受体CXCR4蛋白和mRNA在大肠腺癌、大肠管状腺瘤、非肿瘤性大肠黏膜组织中的表达,探讨二者在大肠腺癌的发生、发展、浸润转移中的作用.方法 采用免疫组化SP两步法和RT-PCR法检测上述3组中SDF-1和CXCR4蛋白、mRNA的表达.结果 (1)免疫组化SP两步法检测SDF-1、CXCR4的蛋白在非肿瘤性大肠黏膜、大肠管状腺瘤、大肠腺癌中的…查看全部>>
Purpose To evaluate the role and clinical significance of SDF-1 ( stromal cell-derived factor-1 ) and its receptor CXCR4 in development, infiltration and metastasis of colorectal carcinoma. Methods The expressions of SDF-1 and its receptor CXCR4 were detected by SP immunohistochemical method and RT-PCR method in three groups. Results ( 1 ) The results of immunochemistry showed the differences of SDF-1 and CXCR4 proteins positive expression among the colorect…查看全部>>
郑淑芳;展晓红;时丽芳;寇天雷;秦晓静;何滔
武警后勤学院附属医院病理科,天津,300162山东省青岛市中心医院病理科,青岛,266042武警后勤学院附属医院病理科,天津,300162武警后勤学院附属医院病理科,天津,300162武警后勤学院附属医院病理科,天津,300162武警后勤学院附属医院病理科,天津,300162
医药卫生
结直肠肿瘤SDF-1CXCR4浸润转移
colorectal neoplasms SDF-1 CXCR4 infiltration metastasis
《临床与实验病理学杂志》 2013 (1)
9-13,5
天津市应用基础及前沿技术研究计划面上项目(11JCY BJC13000),武警后勤学院面上项目(WYMZ201009)
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