中国临床保健杂志2013，Vol.16Issue(1)：7-10,4.DOI:10.3969/J.issn.1672-6790.2013.01.003
原发性高血压患者血压变异性和血清高敏C反应蛋白及基质金属蛋白酶-9关系的研究
Relationship between blood pressure variability and serum high sensitive C-reactive protein and matrix metalloproteinase-9 in patients with essential hypertension
王良勇 1谈敏 1常虹1
作者信息
- 1. 安徽医科大学附属省立医院、安徽省立医院干部病房,合肥,230001
- 折叠
摘要
Abstract
Objective To sludy the relationship belween blood pressure variability ( BPV) and serum high sensilive C-reactive prolein ( hs-CRP) and malrix metalloproleinase-9 ( MMP-9) in palienls wilh essenlial hypertension. Methods A total of149 palienls were included in the sludy. The participants were divided into two groups, those wilh hypertension (n = 117) and those wilhoul hypertension ( n = 32) . According to the results of 24 h ambula-tory blood pressure monitoring for the selected 117 cases wilh essential hypertension, the patients wilh hypertension were divided into low and high variability groups according to the 50 th percentile of 24 h SBPV. Hs-CRP was measured with turbidimetry and MMP-9 with enzyme linked immunosorbent assay ( ELISA) in the total patients. Results The patients with essential hypertension had significantly higher 24 h SBPV( P < 0. 01) than those without hypertension. Serum hs-CRP and MMP-9 also were significantly higher in the patients with hypertension than those without hypertension ( P <0. 01) . Compared with the patients with lower BPV, the serum hs-CRP and MMP-9 increased significantly in the patients with higher BPV ( P < 0. 01) . Pearson relation analysis showed that 24 h SBPV level had significant positive correlation with age, course of disease, LDL-C, hs-CRP and MMP-9 in patients with hypertension. Multi-variate regression analysis showed that the LDL-C, hs-CRP, MMP-9 were predictors of 24 hSBPV levels. Conclusion The BPV is related to hs-CRP and MMP-9 in patients with essential hypertension.关键词
高血压/血压测定/C反应蛋白质/基质金属蛋白酶9Key words
Hypertension/ Blood pressure determination/ C-reactive protein/ Matrix metalloproteinase9分类
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王良勇,谈敏,常虹..原发性高血压患者血压变异性和血清高敏C反应蛋白及基质金属蛋白酶-9关系的研究[J].中国临床保健杂志,2013,16(1):7-10,4.
