环境与职业医学2012，Vol.29Issue(12)：735-738,4.
900MHz微波辐射对雄性大鼠血浆激素水平昼夜节律的影响
Effects of 900 MHz Microwave Radiation on Circadian Rhythm of Plasma Hormone Level in Male Rats
摘要
Abstract
[ Objective ] To investigate the effects of 900 MHz microwave radiation on circadian rhythm of melatonin, testosterone, and estradiol levels in plasma of male rats. [ Methods ] The locomotor activity of 30 adult male SD rats were measured after 30 d of adaption and fitted to a single cosine curve with a 24 h cycle for circadian rhythm screening. After that 10 out of 17 rats with similar circadian rhythm of melatonin levels in plasma were randomly divided into a control group and a radiation group (5 rats for each group). The latter was exposed to microwave radiation (2 000 μW/cm2, 900 MHz, 1 h/d, 30 d) at zeitgeber time (ZT) 1. The control group was treated in the same condition of the radiation group except radiation. Blood samples were collected from caudal vein every 4h after the last radiation exposure. Testosterone, estradiol, and melatonin levels in plasma of blood samples were determined and fitted to phase response curves (PRCs) using a cosine model. [ Results ] The mesor, amplitude, and acrophase of PRCs for plasma melatonin level and testosterone level showed significant differences between the control group and the radiation group (P<0.05). The plasma estradiol levels presented significant circadian rhythm in the control group, but not in the radiation group. [ Conclusion ] The findings indicate that 2000μW/cm2, 900 MHz microwave radiation can affect the circadian rhythm of plasma testosterone, estradiol, and melatonin levels in male rats.关键词
微波辐射/昼夜节律/褪黑素/睾酮/雌二醇Key words
microwave radiation/ circadian rhythm/ melatonin/ testosterone/ estradiol分类
医药卫生引用本文复制引用
赵华,宗春燕,周振,姜秉成,胡文珠,童建,曹毅..900MHz微波辐射对雄性大鼠血浆激素水平昼夜节律的影响[J].环境与职业医学,2012,29(12):735-738,4.基金项目
973项目资助课题(编号:2011CB503700) （编号:2011CB503700）
