老年心脏病学杂志（英文版）2012，Vol.9Issue(4)：401-407,7.DOI:10.3724/SP.J.1263.2012.12282
High density lipoproteins and atherosclerosis: emerging aspects
High density lipoproteins and atherosclerosis: emerging aspects
Federica Sala 1Alberico Luigi Catapano 1Giuseppe Danilo Norata2
作者信息
- 1. Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy
- 2. IRCCS Multimedica, Via Milanese 300, Sesto San Giovanni, Milan, Italy
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摘要
Abstract
High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes.Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.关键词
High density lipoproteins/ Apolipoprotein/ Sphingosine-1-phosphate/ Immune responseKey words
High density lipoproteins/ Apolipoprotein/ Sphingosine-1-phosphate/ Immune response引用本文复制引用
Federica Sala,Alberico Luigi Catapano,Giuseppe Danilo Norata..High density lipoproteins and atherosclerosis: emerging aspects[J].老年心脏病学杂志（英文版）,2012,9(4):401-407,7.
