南京医科大学学报（自然科学版）2012，Vol.32Issue(11)：1561-1564,4.
肝硬化患者中白细胞介素17A水平及临床意义
Interleukin-17A level in patients with liver cirrhosis and its clinical significances
摘要
Abstract
Objective:To observe the expression and location of IL-17A in the liver fibrosis and evaluate the clinical significances of IL-17A. Methods:The peripheral blood and liver tissue was collected from the patients with liver fibrosis. The serum IL-17A level was assayed by ELISA,and the expression and location of IL-17A in the liver tissue was detected by immunohistochemistry. Results: Serum IL-17A level was significantly higher in cirrhotic patients than in control. IL-17A was mainly expressed in hepatic stellate cells, infiltrative neutrophil and lymphocyte, and bile ducts epithelium in the liver fibrosis tissue. The IL-17A expression in liver was correlated with Child-Pugh grades. Conclusion:IL-17A is critical in liver fibrosis,and the expression level of IL-17A may indicated the severity of liver fibrosis.关键词
白细胞介素17A/肝硬化/临床分析Key words
interleukin -17A/liver fibrosis/clinical analysis分类
医药卫生引用本文复制引用
钱晓峰,谭忠明,孙倍成,王学浩..肝硬化患者中白细胞介素17A水平及临床意义[J].南京医科大学学报（自然科学版）,2012,32(11):1561-1564,4.基金项目
江苏高校优势学科建设工程项目(JX10231081) （JX10231081）
江苏省研究生培养创新工程(CXZZ12_0578) （CXZZ12_0578）
