南京医科大学学报（自然科学版）2012，Vol.32Issue(11)：1570-1574,5.
基质金属蛋白酶9及其组织型抑制剂1水平与老年脑梗死患者颈动脉粥样硬化程度的关系
Relation of matrix metalloproteinase-9 and its inhibitor with carotid artery atherosclerosis in aged patients with cerebral infarction
刘庆萍 1吴岩峰 1王辉1
作者信息
- 1. 南京医科大学第二附属医院神经内科,江苏南京210003
- 折叠
摘要
Abstract
Objective:To study the relation of serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) with carotid artery atherosclerosis in elderly patients with cerebral infarction. Methods:Two hundred and sixty patients with cerebral infarction were divided into normal intimated thickness (IMT) group (n = 24) ,increased IMT group (n = 62) ,stable plaque group (n = 110) and unstable plaque group(n = 64). Their IMT and carotid plaques were detected by high resolution B mode ultrasonography. And their serum levels of biochemical indicators,MMP-9 and TIMP-1,were measured and compared. Results:The serum MMP-9 and TIMP-1 levels increased gradually in the 4 groups and were higher in the unstable plaque group than in the other three groups (P < 0.01). Logistic regression analysis showed that the arotid artery atherosclerosis was positively correlated with the body mass index (BMI),systolic blood pressure (SBP),triglycerides (TG),and 1gMMP-9 of patients with cerebral infarction. And the stability of carotid plaque was positively correlated with the BMI,TG and lgMMP-9. Conclusion:Serum MMP-9 and TIMP-1 levels are closely related with stability of carotid plaque in aged patients with cerebral infarction.关键词
脑梗死/颈动脉粥样硬化/基质金属蛋白酶9/组织基质金属蛋白酶1抑制剂Key words
cerebral infarction/carotid artery atherosclerosis/matrix metalloproteinase 9/tissue inhibitor of metalloproteinase-1分类
医药卫生引用本文复制引用
刘庆萍,吴岩峰,王辉..基质金属蛋白酶9及其组织型抑制剂1水平与老年脑梗死患者颈动脉粥样硬化程度的关系[J].南京医科大学学报（自然科学版）,2012,32(11):1570-1574,5.
