南京医科大学学报（自然科学版）2012，Vol.32Issue(11)：1575-1578,4.
维生素D受体mRNA及其蛋白在不同体质指数人群皮下和大网膜脂肪组织中的表达差异
The mRNA and protein expression differences of vitamin D receptor in subcutaneous and omental adipose tissues of people with different BMI
摘要
Abstract
Objective:To investigate the mRNA and protein expression differences of vitamin D receptor (VDR) in subcutaneous and omental adipose tissue of people with different BMI. Methods:Twenty people of normal BMI,35 people of overweight and 27 people of obesity were selected. The mRNA transcription levels of VDR were assayed by RT-PCR,and the VDR protein expression was measured by Western blot. Results: CD In subcutaneous obesity tissue,mRNA transcription and protein expression of VDR was lower in obesity group than in the normal or overweight group (P < 0.05); (D In omental adipose tissue, mRNA transcription and protein expression of VDR was highest in overweight group among 3 groups (P < 0.05). Compared with the overweight group,mRNA transcription and protein expression of VDR was lower in obesity group(P < 0.05). Conclusion:The VDR expression decreased in the obesity group, which may be one of the mechanisms of the poor clinical outcome of vitamin D intervention therapy.关键词
皮下脂肪/大网膜脂肪/维生素D/维生素D受体Key words
subcutaneous fat/omental adipose tissue/vitamin D/vitamin D receptor分类
医药卫生引用本文复制引用
徐家蓉,张力翔,缪珩..维生素D受体mRNA及其蛋白在不同体质指数人群皮下和大网膜脂肪组织中的表达差异[J].南京医科大学学报（自然科学版）,2012,32(11):1575-1578,4.基金项目
南京医科大学科技发展基金(2010NJMUZ50) （2010NJMUZ50）
