内科理论与实践2013，Vol.8Issue(1)：45-48,4.DOI:10.3969/j.issn.1673-6087.2013.01.011
他汀类药物治疗慢性心力衰竭的疗效及预后影响研究
The therapeutic and prognostic effect of statins on chronic heart failure
苏倩 1吴穷 1柴熙晨 1李金平 1应晨 1潘文麒1
作者信息
- 1. 上海交通大学医学院附属瑞金医院心内科,上海200025
- 折叠
摘要
Abstract
Objective To evaluate the therapeutic and prognostic effect of statins in patients with chronic heart failure (CHF). Methods A total of 240 heart failure patients with New York Heart Association (NYHA) Class Ⅱ -Ⅳ [left ventricular ejection fraction (LVEF ≤45%)] from our hospital, Lu Wan District Central Hospital and Min Hang District Central Hospital were enrolled in this study. Patients were assigned into two group with 120 patients each according to whether statins was taken or not. The changes of cholesterol level, serum N-terminal probrain natriuretic peptide (NT-proBNP), high sensitive C reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), and the differences of LVEF and cardiac chamber size by echocardiography monitoring before and after treatment were compared between the two groups. Furthermore, the survival rate and endpoint event rate were compared. Results As compared with non-statins group, serum NT-proBNP, hs-CRP and TNF-α were decreased significantly in statins group, while LVEF was increased (41.5% vs 42.8%, P=0.034) and cardiac chamber size was reduced. Survival rate increased (92.5% vs 80.8%, P=0.013) and end point event rate decreased in statins group (38.3% vs 57.5%, P=0.006). Conclusions CHF patients treated with statins had a lower serum cholesterol, NT-proBNP, hs-CRP and TNF-α level and reduced cardiac chamber size, but higher LVEF and survival rate and fewer endpoint events, suggesting that statins could improve the prognosis of CHF.关键词
慢性心力衰竭/羟甲基戊二酸辅酶A还原酶抑制剂/生存率/终点事件Key words
Chronic heart failure / 3-hydroxy-3 methyl-glutaryl-coenzyme A reductase inhibitor/ Survival rate/ Endpoint event分类
医药卫生引用本文复制引用
苏倩,吴穷,柴熙晨,李金平,应晨,潘文麒..他汀类药物治疗慢性心力衰竭的疗效及预后影响研究[J].内科理论与实践,2013,8(1):45-48,4.
