摘要
Abstract
Objective This study evaluated the efficacy and side effects of stereotactic body radiation therapy (SBRT) combined with chemotherapy in the treatment for inoperable or refused surgery locally advanced ( World Health Organization stage Ⅲ A、ⅢB) non-small cell lung cancer patients. Methods From August 2006 to February 2009,110 patients with locally advanced non-small cell lung cancer were randomly divided into Treatment Group and Control Group in this study. Treatment Group: SBRT combined with chemotherapy. SBRT with schema-periphery dose 350cGy ～400cGy per fraction (50% dose line) ,12 ～ 14 fractions was carried out, at a total dose of 49Gy ～ 56Gy. Chemotherapy with TP regimen 4 cycles was performed one week after SBRT. Control Group: Conventional radiotherapy combined with chemotherapy, dose 180cGy ～ 200cGy per fraction, 25 fractions was carried out, at a total dose of 50Gy ～54Gy. Chemotherapy with the same as Treatment Group' s. Results Effective rate, 1-year survival and 2-year survival, radiation pneumonitis incidence of the Treatment Group is 81.94%, 65. 28% , 47. 22% , 3. 57% ,and the Control Group' s is 63.16% , 39. 47% , 23. 68% , 16. 67% , respectively. Conclusion SBRT combined with chemotherapy may have short-term efficacy for the inoperable or refused surgery local advanced non-small cell lung cancer with mild toxicity.关键词
体部立体定向放射治疗/局部晚期/非小细胞肺癌Key words
stereotactic body radiation therapy/local advanced/non-small cell lung cancer分类
医药卫生
