四川医学2012，Vol.33Issue(11)：1922-1925,4.
窒息新生儿尿系列微量蛋白与肾血流动力学改变的研究
Changes and related research of urine microprotein and renal blood flow in newborns with asphyxia
杜逸亭 1王译 1李丽 2罗德幸 1郑毅1
作者信息
- 1. 成都市妇女儿童中心医院新生儿科,四川成都610091
- 2. 安琪儿妇产医院,四川成都610041
- 折叠
摘要
Abstract
Objective To observe correlation of microproteinuria and renal blood flow in newborns with diferent asphyxia. Methods Four urinary minimal proteins-albumin (Alb), transferrin(TRF) , β2-microglobulin ( β2-MG), al-microglobulin
(al-MG)as well as serum creatinine(Cr) were measured in 30 mild asphyxia infants, 22 severe asphyxia infants and 26 normal infants, and color Doppler ultrasound technology was adopted to monitor the changes of renal hemodynamicindex on the first day. Results The urinary levels of4 measured proteins were much higher in the asphyxia groups (P<0.05) , while there was no significant difference in scram Cr levels ( P > 0. 05 ) . On the first day after birth, the rate of renal aorta blood flow in neonatal group of asphyxia was lower than that in normal neonatal group ( P < 0. 05 ) ; and renal aorta resistance was higher in asphyxia group ( P < 0. 05 ). The change in mild asphyxia was obvious, but the change in severe asphyxia was even more obvious. The rate of renal aorta blood flow and measurements of urine four minimal proteins were negatively correlated. Aorta resistance and measurements of urine four minimal proteins were positively correlated. The renal blood flow parameters PSFV, EDFV and urine protein were negatively correlated ( P < 0. 05 ) , RI, PI and urine protein were positivly correlated (P < 0. 01). Conclusion The test of renal blood flow can eslimat the level of protein in urine. Similarly,according to the levels of urine protein, we can estimate the situation of renal blood flow. The test of u-rine four minimal proteins and renal hemodynamic index play an important role for the early diagnosis of impaired renal function in newborns with asphyxia.
关键词
窒息/新生儿/尿微量蛋白/肾血流动力学/肾功能Key words
asphyxia/newborn/urine microprotein/renal circulation/renal function分类
医药卫生引用本文复制引用
杜逸亭,王译,李丽,罗德幸,郑毅..窒息新生儿尿系列微量蛋白与肾血流动力学改变的研究[J].四川医学,2012,33(11):1922-1925,4.
