四川医学2012，Vol.33Issue(12)：2055-2057,3.
不同限食方式对肥胖大鼠下丘脑orexin mRNA表达的影响
The effect of differential fasting on orexin mRNA in the hypothalamus of obese rats
摘要
Abstract
Objective To explore the effect of differential fasting on orexin mRNA in the hypothalamus of obese rats; Methods Establishment model of high fat diet induced obese rats, differential feeding condition of orexin mRNA expression in hypothalamus of rats were detected by the RT-PCR. Results Orexin mRNA expression of obese control group showed significantly increase than that of basic control group; orexin mRNA expression of obese 80% high fat diet group showed significantly difference than that of obese control group and basic control group at 12 weeks; orexin mRNA expression in obese 60% high fat diet group demonstrated significantly increase than that in obese control group; orexin of obese 100% standard diet group and obese 80% standard diet group showed significantly difference than that of obese control group and basic control group at 12 weeks; compared to obese 80% high fat diet group, orexin expression of obese 100% standard diet group showed significant increase al 12 weeks; orexin mRNA expression of obese 60% standard diet group was very low. Conclusion Diet construction was key in improving orexin expression, adjust of diet construction was more effectively than decrease of diet mount.关键词
肥胖/大鼠/下丘脑/orexinKey words
obesity/ rat/ hypothalamus/ orexin分类
医药卫生引用本文复制引用
赵琳,贾鲲鹏,王璐,刘伯锋..不同限食方式对肥胖大鼠下丘脑orexin mRNA表达的影响[J].四川医学,2012,33(12):2055-2057,3.基金项目
延安大学自然科学专项科研项目(编号:YD2010-02) （编号:YD2010-02）
