山东医药2012，Vol.52Issue(46)：19-21,3.
膀胱移行细胞癌术后复发与染色体畸变的相关性研究
Study on the correlation of postoperative recurrence and chromosome aberration of the transitional cell carcinoma of bladder
摘要
Abstract
Objective To investigate the relevance and clinical significance of the postoperative recurrence and chromosomal aberrations in the transitional cell carcinoma of bladder ( TCCB ) . Methods Fluorescence in situ hybridization was used to detect the chromosome aberrations of 3,7 and 17 and 9 pl6 gene in 35 cases patients of transitional cell carcinoma of bladder,including 19 cases patients who were recurrence and 16 cases who were non-recurrence. Ten cases of adjacent normal tissue were chosen as control. Results The rate of chromosome 3,7,17 and 9 pl6 aberration in 19 cases of recurrent TCCB tissues were 42. 11%, 57. 89% , 84.21% and 89.47%. Rate in 16 cases of non-recurrence TCCB tissues were 31. 25% , 37.50% , 43.75% and 50.00%. The rate of chromosomes 17 and 9pl6 aberration in the recurrence TCCB tissues were obviously higher than the non-recurrence (all P < 0.05). The aberration and recurrence showed a positive correlation (r were 0.391 and 0.399 respectively, all P<0.05). There were significant difference between G, and G2_3 levels in chromosome 7 of recurrence TCCB tissues (P <0.05). The aberration and recurrence showed a positive correlation( r was 0.565 ,P < 0.05). The chromosomes changes above were not associated with pathological stage or the numbers of recurrences (all P>0.05). Conclusions There was positive correlation between the postoperative recurrence of transitional cell carcinoma of bladder and chromosome aberrations of chromosome 9 pl6 gene and chromosome 17. In the recurrent TCCB , there was a positive correlation between the aberration of chromosome 7 and histologic grade. Monitoring FISH regularly for the postoperative TCCB patients has important clinical significance for the early detection of disease and treatment in time.关键词
膀胱肿瘤/膀胱移行细胞癌/染色体畸变Key words
bladder tumor/ transitional cell carcinoma of bladder/ chromosomal aberrations分类
医药卫生引用本文复制引用
张婷婷,李锦毅..膀胱移行细胞癌术后复发与染色体畸变的相关性研究[J].山东医药,2012,52(46):19-21,3.基金项目
国家自然科学基金资助项目(81072969) （81072969）
卫生部科研基金资助项目(WKJ2007-3-001). （WKJ2007-3-001）
