山东医药2012，Vol.52Issue(48)：14-16,3.
高血压病不同左室构型患者血清hs-CRP、ADMA水平变化及意义
Correlation of high sensitive C reactive protein and asymmetric dimethylarginine with left ventricle of essential hypertension
摘要
Abstract
Objective To study the level of high sensitive C reactive protein (hs-CRP) and asymmetric dimethylar-gininein ( ADMA) in serum of health adults and essential hypertension patients with different left ventricle, and to explore the effect of hs-CRP and ADMA on hypertension and hypertension left ventricle. Methods To select 30 health adults as control (A group) and essential hypertension patients 131. According to left ventricular mass index ( LVMI) and relative wall thickness (RWT) , hypertension patients were divided into 4 groups; normal left ventricle group with normal LVMI and RWT, concent ric remolding group with normal LVMI and incremental RWT, typical concentric hypertrophy group with incremental LVMI and RWT, eccentric left ventricular group incremental LVMI and normal RWT. To test hs-CRP by re-forced enulsion immunoturbidimetry and ADMA by reversed phase high-performance liquid chromatography in the serum of each group. Results Compared with control, hs-CRP, ADMA were obviously higher in the hypertension group (P < 0. 01 ). hs-CRP increased with the severity of the left ventricle, and the difference between left ventricle groups had statistical significance. ADMA had no regularity. hs-CRP had positive correlation with LVMI and RWT, but ADMA had no correlation with them. Conclusions hs-CRP and ADMA participate in the development of hypertention. Only ADMA participates in the development of left ventricle.关键词
高血压病/高敏C反应蛋白/非对称性二甲基精氨酸/左室构型Key words
essentional hyertension/ high sensitive C reactive protein/ asymmetric dimethylarginine/ left ventricle分类
医药卫生引用本文复制引用
李鑫,蔡久英,占育飞..高血压病不同左室构型患者血清hs-CRP、ADMA水平变化及意义[J].山东医药,2012,52(48):14-16,3.基金项目
辽宁省医药卫生科研基金资助项目(20060517). （20060517）
