山东医药2013，Vol.53Issue(3)：19-21,3.DOI:10.3969/j.issn.1002-266X.2013.03.007
支原体肺炎患儿血清炎性细胞因子、免疫球蛋白、补体、hs-CRP水平变化及意义
Level changes and significance of serum cytokine, Ig, complement, hs-CRP in children with mycoplasma pneumonia
摘要
Abstract
Objective To observe the changes of serum cytokine(IL-2 and IL-6) , imunoglobulin (Ig) , complement, high-sensitivity C-reactive protein (hs-CRP) in children with mycoplasma pneumonia (MPP)and to probe into the clinical significance. Methods 50 children with MPP (the observed group, of whom 28 were severe cases and 22 were mild cases) and 42 healthy children (the matched group)were enrolled, ELISA was used to determine the ordinary pneumonia serum IL-2, IL-6 levels, scattering rate turbidime-tric method was used to determine the contents and composition of hs-CRP, Ig and complement (C3, C4). Results Compared with matched group, during the severe period, IL-2 and IgA levels in the observed group decreased, levels of IL-6, hs-CRP, IgM , IgG, C3 , C4 increased(P <0. 05 or 0.01) ; whereas during convalescence period, IL-2 level decreased, levels of hs-CRP, IgG increased(P <0. 05 or 0.01). Compared with convalescence, IL-2 level in the observed group decreased, levels of IL-6, hs-CRP, C3 increased(P <0. 01). Compared with mild cases, levels of IL-2, IgA in severe cases decreased, levels of IL-6, hs-CRP, IgM, IgG, C3, C4 increased (P< 0.05 or <0.01). IL-6 concentration was negatively correlated with the IL-2 level in MPP patients( r = -0.634, P=0.017). Conclusions Serum cytokine, Ig, complement, hs-CRP in children with MPP decrease or increase during severe and convalescence period or in severe and mild cases; The detection of these indexes will facilitate determining the state of illness and prognosis and help guide the therapy of MPP.关键词
小儿支原体肺炎/白细胞介素-2/白细胞介素-6/免疫球蛋白/血清补体Key words
mycoplasma pneumonia in children/ interleukin-2/ interleukin-6/ immunoglobulin/ serum complement分类
医药卫生引用本文复制引用
袁浩,李登清..支原体肺炎患儿血清炎性细胞因子、免疫球蛋白、补体、hs-CRP水平变化及意义[J].山东医药,2013,53(3):19-21,3.基金项目
湖南省标准化战略项目(2011-494). （2011-494）
