山东医药2013，Vol.53Issue(3)：22-24,3.DOI:10.3969/j.issn.1002-266X.2013.03.008
胃癌组织中c-FLIP、NF-κB p65的表达变化及意义
Expression and clinical significance of c-FLIP and NF-κB p65 in gastric carcinoma tissue
陈军 1覃思繁 1林思彤 1韦常宏1
作者信息
- 1. 广西医科大学附属肿瘤医院,南宁530021
- 折叠
摘要
Abstract
Objective To investigate the roles of cellular Fas-associated death domain-like interleulin-1 0 converting engyme inhibitory protein (c-FLIP) and nuclear factor kappa B(NF-κB) p65 in the incidence and development of gastric carcinoma. Methods Collected 80 cases of gastric carcinoma tissue ( gastric carcinoma group) and 80 cases of paired adjacent gastric tissue( adjacent gastric carcinoma group) , immunohistochemisty was employed to determine the expression of c-FLIP and NF-κB p65 in the two groups. The relationship between c-FLIP and NF-κB p65, and their correlation with clinical parameters was analyzed. Results The positive rate of c-FLIP and NF- κB p65 was significantly higher in gastric carcinoma group than in adjacent gastric carcinoma group ( all P < 0.05). The expression of c-FLJP was significantly correlated with the clinical stage, the degree of tumor differentiation, the lymph node metastasis and the recurrence of tumor (all P < 0.05 ). The expression of NF-kB p65 was significantly correlated with the invaded depth, the degree of tumor differentiation , the lymph node metastasis and the recurrence of tumor (all P < 0.05 ) . There was a significantly positive relationship of c-FLIP with NF-κB p65 ( r = 0. 303 , P = 0. 006 ) . Conclusion The overexpression of c-FLIP and NF-kB p65 might play important roles in the incidence and development of gastric carcinoma.关键词
胃肿瘤,胃癌/细胞型Fas相关的死亡区域蛋白样白介素-1转换酶抑制蛋白/细胞核因子kappa B p65/免疫组织化学Key words
gastric carcinoma/ apoptosis/ cellular Fas-associated death domain-like interleulin-1 β converting engyme inhibitory protein/ nuclear factor kappa B p65/ immunohisto-chemistry分类
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陈军,覃思繁,林思彤,韦常宏..胃癌组织中c-FLIP、NF-κB p65的表达变化及意义[J].山东医药,2013,53(3):22-24,3.
