山东医药2013，Vol.53Issue(3)：28-30,3.DOI:10.3969/j.issn.1002-266X.2013.03.010
二膦酸盐局部注射对去势正畸牙大鼠牙周组织改建的影响
Effects of Zoledronate solution on experimental remodeling of powered periodontal tissues in adult rats
摘要
Abstract
Objective To investigate the effect of Zoledronate solution on distance of tooth movement and number of osteoclasts after the experimental remodeling of powered periodontal tissues taken orthodontic tooth movement in ovariecto-mized adult rats. Methods Sixty 10 week old female Wister rats were randomly divided into three groups; the model group, the control group and the Zoledronate solution group. Phony oophoreetomy was conducted to the rats in the control group, and the bilateral oophorectomy which was carried out by making bilateral waist-back incision was conducted to the rats in the model group and the Zoledronate solution group to form the ovariectomized rat model. 7 weeks after that surgery, orthodontic tooth movement model was built in all the three groups. In this model, the rat's first molar of maxillary was dragged to the mesial, the orthodontic force of which was adjusted to 30 g. Three days before the force was made, 50 μL Zoledronate solution (500 μmol/L) was injected to the mucoperiosteal that was near the furcation in the Zoledronate solution group rats first molar, meanwhile, the rats in the other two groups were injected the same amount of saline in the same site. The rats in the model group and the Zoledronate solution group were put to death in the 3th, 7th, 14th and 21th day after the traction. The orthodontic tooth movement models were established by operation. The distance of tooth movement was measured and the periodontal tissues were histologically studied. Results Compared with the model group and control group, the distance of tooth movement in Zoledronate solution group reduced significantly at 7, 14 and 21 d ( all P < 0. 05 ) ; Compared with the control group, the distance of tooth movement in model group increased significantly at 7, 14 and 21 d (all P < 0. 05). Compared with the model group and control group, the quantity of osteoclasts in Zoledronate solution group reduced significantly at 7, 14 and 21 d( all P <0. 05 ) ; Compared with the control group, the quantity of osteoclasts in model group increased significantly at 7 , 14 and 21 d( all P < 0. 05). Conclusions Local delivery of Zoledronate solution can inhibit osteoclastogenesis and tooth movement, which is good for periodontal tissue remodeling.关键词
二膦酸盐/去势大鼠/牙周组织改建Key words
Zoledronate solution/ ovariectomized rat/ periodontal tissue remodeling分类
医药卫生引用本文复制引用
任旭升,徐杰,王旭霞,孙学恭,张君..二膦酸盐局部注射对去势正畸牙大鼠牙周组织改建的影响[J].山东医药,2013,53(3):28-30,3.基金项目
山东省科技发展计划项目(2009GG20002042). （2009GG20002042）
