山东医药2013，Vol.53Issue(5)：36-38,3.DOI:10.3969/j.issn.1002-266X.2013.05.012
原发性高血压患者子代人群载脂蛋白E基因多态性与高血压的关系
Relationship between polymorphisms of apolipoprotein E gene and hypertension of essential hypertension filial generation
摘要
Abstract
Objective To investigate the relationship between polymorphisms of apolipoprotein E ( ApoE) gene and hypertension of essential hypertension filial generation. Methods ApoE gene polymorphism was genotyped in 60 cases with essential hypertension filial generation (case group) and 60 normal cases (control group) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and the relationship between polymorphisms of ApoE gene and hypertension was analyzed. Results All the research object of PCR fragments were satisfied with amplification, a total of 6 kinds of of genetic type were detected, the Hardy-Weinberg balance test was achieved linkage equilibrium, with group representative. In the two groups, ApoE3/3 was the dominant type, but there was no statistical difference in the all genotypes. In the two groups, e3 allele frequency was the highest and e2 was lowest. The e4 allele frequency was higher in case group than that in control group(x2 =12.42, P <0.05). Conclusions The ApoE e4 allele may be a hypertension susceptibity gene, the occurrence of hypertension might be correlative with a variety of factors, such as environment.关键词
高血压/载脂蛋白E类/多态性,单核苷酸Key words
hypertension/ apolipoproteins E/ polymorphism, single nucleotide分类
医药卫生引用本文复制引用
容春莉,于薇,姚文静,李如意,曹东平,彭应心..原发性高血压患者子代人群载脂蛋白E基因多态性与高血压的关系[J].山东医药,2013,53(5):36-38,3.基金项目
河北省卫生厅医学科学研究重点指导性课题(07165). （07165）
