生物加工过程2012，Vol.10Issue(6)：70-77,8.DOI:10.3969/j.issn.1672-3678.2012.06.015
基因组规模代谢网络模型的约束算法及其应用
Constraint-based algorithms for genome scale metabolic model-a review
摘要
Abstract
In order to further increase the efficiency of microbial manufacturing process, a key step was to improve the microbial phenotype. Combined with the constraint-based algorithms,a genome-scale metabolic model provided a global platform for comprehensive, understanding, manipulation and optimization of the industrial strain physiological functions. In this paper,the reconstruction process of genome-scale metabolic model was firstly described. And then the principle,the classification, and the application of the constraint-based algorithms for the genome scale metabolic model were outlined. Furthermore, the prospective and the tendency of algorithms were given.关键词
基因组规模代谢网络模型/基于约束的算法/工业微生物Key words
genome scale metabolic model/constraint-based algorithms/industrial strain分类
生物科学引用本文复制引用
刘立明,刘婷,邹伟..基因组规模代谢网络模型的约束算法及其应用[J].生物加工过程,2012,10(6):70-77,8.基金项目
教育部新世纪优秀人才支持计划资助项目(NCET-10-0456) （NCET-10-0456）
江苏省杰出青年基金资助项目(BK2012002) （BK2012002）
中组部首批青年拔尖人才支持计划资助项目 （）
