陕西师范大学学报（自然科学版）2013，Vol.41Issue(1)：53-58,6.
内分泌干扰物对雌激素受体信号通路的影响
The impact of endocrine disruptive chemicals on estrogen receptor signal pathway
摘要
Abstract
The endocrine disrupting chemicals (EDCs) can affect transcriptional activities via influencing estrogen receptors (ER) signaling pathway. This review focus on the mechanism about effect of EDCs on ERs signal pathway. The characteristic and signal pathway of the two estrogen receptors (ERs), ERα and ERβ, were firstly expatiated. The effect of EDCs on ER signaling pathways are consist of the ligand-dependent and non-ligand-dependent pathway, and the ligand-dependent pathways include the modes of direct and indirect action. The direct action of EDCs can change the transcriptional activity of ER through the competive binding between EDCs as ligand and estragen to the same site. The indirect action is mainly regarded that the aryl hydrocarbon receptor (AhR) can be activated by EDCs as ligand, then AhR makes ERs being ubiquitinated and degradated, or competitive binding the co-activator with ER or direct disrupting the DNA transcription. The mechanisms of EDCs disrupting the internal secretion involving non-ligand-dependent and non- gene pathway are not clear. This review prompted that the research on EDCs' s effect should be paid more attention to exploring the mechanism about multi signals pathways in future.关键词
内分泌干扰物/雌激素受体/信号通路Key words
endocrine disruptive chemicals/ estrogen receptor/ signal transduction分类
生物科学引用本文复制引用
张育辉,肖宁,李忻怡..内分泌干扰物对雌激素受体信号通路的影响[J].陕西师范大学学报（自然科学版）,2013,41(1):53-58,6.基金项目
国家自然科学基金资助项目(30770243) （30770243）
中央高校基本科研业务费专项资金项目(GK200902039). （GK200902039）
