山西医科大学学报2012，Vol.43Issue(10)：743-746,4.DOI:10.3969/J.ISSN.1007-6611.2012.10.006
季铵化程度对N-三甲基壳聚糖包衣的司帕沙星脂质体体外性质的影响
Effect of degree of quaternization on the in vitro properties of N-trimethyl chitosan-coated sparfloxacin liposomes
彭爱华 1郭咸希 2何文2
作者信息
- 1. 湖北荆门沙洋人民医院药剂科,荆门,448200
- 2. 武汉大学人民医院药学部
- 折叠
摘要
Abstract
Objective To explore the effect of degree of quaternization( DQ ) on the in vitro properties of N-trimethyl chitosan ( TMC )-coated sparfloxacin liposomes( SFL ). Methods The morphology, size, Zeta potential, entrapment efficacy( EE ) and the in vitro drug release of SFL with and without TMC-coating were compared. Results Compared with un-coated SFL, the size of TMC-coated SFL was increased,Zeta potential changed from negative charge to positive charge, the drug release rate was decreased, while EE kept stable. With the increase of DQ,both the size and the Zeta potential of TMC-coated SFL were increased,and the drug release rate was reduced gradually. Conclusion DQ of TMC may have effect on the in vitro properties of TMC-coated SFL to some extent.关键词
季铵化程度/N-三甲基壳聚糖/司帕沙星/脂质体/体外性质Key words
degree of quaternization/ N-trimethyl chitosan/ sparfloxacin/ liposomes/ in vitro properties分类
医药卫生引用本文复制引用
彭爱华,郭咸希,何文..季铵化程度对N-三甲基壳聚糖包衣的司帕沙星脂质体体外性质的影响[J].山西医科大学学报,2012,43(10):743-746,4.
