山西医科大学学报2012，Vol.43Issue(11)：813-816,824,885,6.DOI:10.3969/J.ISSN.1007-6611.2012.11.003
hMSH2-118T＞C基因多态性与宫颈癌易感的相关性研究
Association between the hMSH2-118T ＞ C polymorphism and the risk for cervical cancer
摘要
Abstract
Objective To investigate the relationship between the hMSH2-118T ＞ C polymorphism and the susceptibility of cervical cancer in ethnic Han Cantonese population. Methods The genotypes of the hMSH2-l 18T ＞ C polymorphism were determined in 113 cervical cancer patients and 280 age-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP). Association between the polymorphism and the risk for cervical cancer was evaluated using unconditional logistic regression analysis. Results No significant difference was observed in the frequency of hMSH2-118T ＞ C between cases and controls(P = 0.91). Taking TT genotype as reference.no significantly increased risk for cervical cancer was observed for those carrying TC or CC genotypes(OR = 1. 10,95 %CI 0. 69 - 1.77;OR = 1. 14,95 %CI 0. 34-3. 82,respectively) . Conclusion The hMSH2-118T ＞ C polymorphism is not associated with the susceptibility of cervical cancer in ethnic Han Cantonese population.关键词
hMSH2/宫颈癌/单核苷酸多态性/遗传易感性Key words
hMSH2/ cervical cancer/ single nucleotide polymorphism/ genetic susceptibility分类
医药卫生引用本文复制引用
曾俐琴,洪小山,熊兴东,李洁明,黄连庆,郭雪贞,罗喜平..hMSH2-118T＞C基因多态性与宫颈癌易感的相关性研究[J].山西医科大学学报,2012,43(11):813-816,824,885,6.基金项目
广东省医学科研基金资助项目(2010068) （2010068）
