山西医科大学学报2013，Vol.44Issue(1)：9-12,4.DOI:10.3969/J.ISSN.1007-6611.2013.01.003
乳腺癌分子生物学指标的表达及与临床病理特征分析
Molecular biological markers expression in breast cancer and its relationship with clinicopathological features
摘要
Abstract
Objective To investigate the expression of estrogen receptor, progesterone receptor, HER-2, Ki-67 in breast cancer and their clinical significance. Methods The expression of ER, PR, HER-2 and Ki-67 was detected in 372 patients with breast cancer and their correlations with clinicopathological features were analyzed. Results ER, PR positive expression rates were significantly lower in patients with lymph node metastasis than those in patients with no lymph node metastasis( P＜0.05 ),while HER-2 and Ki-67 positive expression rates were higher( P ＜0. 05 ). ER,PR positive expression rates were lower in patients with tumor size ＞20 mm than those in patients with tumor size ＜ 20 mm( P ＜0. 05 ), while HER-2 and Ki-67 positive expression rates were higher( P ＜ 0. 05 ). Expression of ER,PR was negatively correlated with HER-2,Ki-67 expression( P ＜0. 05 ). Conclusion ER,PR and HER-2,Ki-67 are valuable for predicting the breast cancer prognosis and providing the individualized treatment.关键词
乳腺癌/分子生物学/病理Key words
breast cancer/ molecular biology/ pathology分类
医药卫生引用本文复制引用
陈伟财,何劲松,吴恢升,王敏,宋淑芬,王先明..乳腺癌分子生物学指标的表达及与临床病理特征分析[J].山西医科大学学报,2013,44(1):9-12,4.基金项目
2012年深圳市科技计划资助项目(201202026) （201202026）
深圳市第二人民医院育苗计划基金资助项目 （）
