现代检验医学杂志2012，Vol.27Issue(6)：19-22,4.DOI:10.3969/j.issn.1671-7414.2012.06.007
中国维族人群DNA酶Ⅰ基因多态性与急性心肌梗死的相关性研究
Study on Correlation of Enzyme Ⅰ Gene Polymorphism with Acute Myocardial Infarction in Uygur Nationality
摘要
Abstract
Objective To investigate the frequency of DNA enzyme I gene polymorphism in Uygurs with acute myocardial infarction and its' association with blood glucose and lipid. Methods 157 cases of acute myocardial infarction patients and 148 cases of healthy controls were selected during the same period. Blood samples of all the 305 Uygurs in Xinjiang were collected. Genomic DNA were extracted from all blood samples, PCR-LDR reaction was employed to detect the A2317G (rsl053874) mutation of Deoxyribonuclease I gene,genotype and allele distribution were analyzed. Meantime,blood glucose and lipid were measured in fasting state by biochemical methods. Results The distribution frequencies of both the genotypes and alleles were significantly different between the control and AMI group. Genotypes of A2317G were not associated with serum total cholesterol,triglyceride,high-density lipoprotein cholesterol and low density lipoprotein-cholesterol (P＞0.05), but were closely related with fasting glucose (P<0. 05). Conclusion The polymorphism of DNA enzyme I gene had a certain relationship with the susceptibility of acute myocardial infarction in Uygurs in Xinjiang. Genotypes of A2317G were not associated with blood lipid,but were closely related with fasting glucose.关键词
脱氧核糖核酸酶Ⅰ/基因多态性/急性心肌梗死/血糖/血脂Key words
DNA enzyme Ⅰ gene,polymorphism,acute myocardial infarction,blood glucose,lipid分类
医药卫生引用本文复制引用
许翔,李莉,高玮,李佳..中国维族人群DNA酶Ⅰ基因多态性与急性心肌梗死的相关性研究[J].现代检验医学杂志,2012,27(6):19-22,4.基金项目
上海市科委西部合作项目《中国汉族及维吾尔族人群DNA酶I基因多态性特点与急性心机梗死的关系》,项目编号:08495801900. （）
