摘要
Abstract
Objective To investigate whether the PR A positivity after living-related kidney transplantation is associated with declining renal function. Methods Atotal of 250 cases were collected from April 2006 to October 2010. There were 188 males and 62 females. They were divided into three groups based on donors' relationship to recipients. They were ① parents' organs to children (125 cases),② children's organs to parents (13 cases) ,and ③ siblings' organs to siblings (112 cases). Follow-up observations were made of the PRA,serum creatine,BUN,and clinical renal function. Results Thirty-eight patients in group ① showed declining renal function and 9 of them were PRA positive. One patient in group ② showed declining renal function with negative PRA and one patient showed positive PRA without declining renal function. Thirteen patients in group ③ showed declining renal function and 3 of them were PRA positive. Of 250 cases ,237 patients were PRA negative,the negative rate being 94.8% ( 237/250), among whom 40 showed declining renal function, accounting for 16. 88% (40/237). 13 patients were PRA positive, the positive rate being 5. 2% (13/250),among whom 12 showed declining renal function,accounting for 92. 31% (12/13). 16. 88% of PRA negative patients showed declining renal failure versus 92. 31% of PRA positive patients (P<0. 01). Group ① showed a higher declining renal function rate of 30. 4% (38/125), compared with the rates of 7. 7% (1/13) and 11. 6% (13/112) in group ② and ③. Conclusion Living-related kidney transplantation resulted in a low PRA positive rate. The PRA positivity is directly associated with declining renal function. A higher rate of renal function decline appears in the group of parents as donors.关键词
亲属肾移植/群体反应性抗体(PRA)/肾功能Key words
living-related kidney transplantation/panel-reactive antibody (PRA)/rena1 function分类
医药卫生
