摘要
Abstract
Objective To evaluate the significance of the serum lipid and apolipoprotein profiles on glycemic control in patients with type 2 diabetes mellitus. Methods A total of 53 patients with type 2 diabetes (30 men, 23 female) were collected in Loudi First People's Hospital from February to July 2012 by randomly selected,and fasting HbAlc,C Peptide (C P) ,tri glycerides (TG) ,total cholesterol (CHO) ,high density lipoprotein C (HDL C) ,apolipoprotein Al (ApoAl) ,apolipoprotein B (ApoB) and lipoprotein A (LPa) levels were measured. They were divided into three groups [group Ⅰ (C P≥0. 6 nmol/L and HbAlc ratio<6. 0%),group Ⅱ (C P>0. 6 nmol/L and HbAlc ratio>6. 0%) , group Ⅲ (C P<0. 6 nmol/L and HbAlc ratio≥6. 0%)] according to C Peptide and HbAlc levels. Results Multi variable analyses showed there were a significant differences in TG (F=4. 33,P<0. 05) ,CHO(F=6. 86,P<0. 05) ,ApoB (F=9. 32,P<0. 001) among three groups. How ever,there were no significant differences in LPa (F=0. 53, P>0. 05) , ApoAl (F= 1. 99, P>0. 05) , HDL C (F=5. 76, P >0. 05) among three groups. Highly significant positive correlations were observed between ApoAl and HDL C levels (r= 0.75,P<0.001) adjusted sex and age. Similarly,CHO and ApoB levels (r=0.78,P<0. 001) displayed a significant positive correlation. Conclusion Lpa is an independent risk factor influencing on the progression of disease with type 2 diabetes mel litus , and the TG is an important risk factor. HDL C/CHO ratio is a more appropriate marker of risk than HDL C levels, and ApoAl/CHO ratio is a more appropriate marker of risk than ApoAl levels.关键词
2型糖尿病/脂类/C-肽/糖化血红蛋白Key words
type 2 diabetes/ lipid profile/C Peptide/ HbAlc分类
医药卫生
