现代检验医学杂志2013，Vol.28Issue(1)：103-105,3.DOI:10.3969/j.issn.1671-7414.2013.01.034
肺结核患者血中CD95与PD-1,PD-L1的检测与分析
Detection and Analysis of CD95 and PD-1,PD-L1 in the Peripheral Blood from Pulmonary Tuberculosis Patients
摘要
Abstract
Objective To investigate the expression of CD95, programed death 1 (PD 1) and its ligands including PD L1 on T lymphocyes in the peripheral blood from pulmonary tuberculosis patients and the role of this expression in genesis and de velopment of chronic tuberculosis pulmonary. Methods 63 initial treatment of active pulmonary tuberculosis patients were detected by Flow Cytometry for partition CD95 and PD 1 ,PD L1 on peripheral blood T lymphocyes, with 28 healthy persons as control group. Results In the initial treating active pulmonary tuberculosis diseas the expression rate of CD95 was (62. 07 ± 14. 87) % ,compared with the control group (35. 74 ± 10. 14) % were significantly increased (t=8. 515, P<0. 05) ;the ex pression rate PD L1 was (26. 55 ± 12. 8) % compared with the control group (18.56 ± 6.46)% was significantly increased (t=3.127,P<0.05);but the levels of PD 1 (13.64 ± 9. 10)% in the supernatant were significantly lower(t=-7. 766, P< 0. 05) ,compared with the control group(28. 71±7. 06) %. Through correlation analysis,the expression levels of CD95 ,PD 1 on the peripheral blood T lymphocyes in patients with pulmonary tuberculosis were positively correlated,and the difference was statistically significant ( r= 0. 279, P<0. 05), but the levels of CD95 and PD L1 did not determine relevance ( r= -0. 025, P>0. 05). Conclusion Presume that high CD95 and PD L1 expression may play a role in the pathogenesis and devel opment of tuberculosis pulmonary.关键词
肺结核/CD95/程序性死亡因子-1Key words
pulmonary tuberculosis /CD95/ programmed death 1分类
医药卫生引用本文复制引用
张健,王昕升,王宝英,宋爱华..肺结核患者血中CD95与PD-1,PD-L1的检测与分析[J].现代检验医学杂志,2013,28(1):103-105,3.基金项目
秦皇岛市科技支撑计划项目(201101A237). （201101A237）
