现代检验医学杂志2013，Vol.28Issue(1)：127-129,132,4.DOI:10.3969/j.issn.1671-7414.2013.01.043
用ROC曲线分析胸腔积液和血清肿瘤标志物联合检测对肺癌的诊断价值
Diagnosis Value of the Lung Cancer Through Analysis the Tumor Markers of Pleural Effusion and Serum Detection with ROC Curve
冯纾琪 1黄钰君 1廖春淼 1周珍文1
作者信息
- 1. 广州市妇女儿童医疗中心儿童院区,广州,510120
- 折叠
摘要
Abstract
Objective To investigate the diagnostic value and the clinical significance of five tumor markers of pleural effusion and serum in patients with lung cancer. Methods The levels of carcinoembryanic antigen(CEA) ,cancer antigen 15 3(CA 15 3) ,cancer antigen 125(CA125) , cytokeratin 19 fragments(CYFRA21 1) and neuron specific enolase (NSE) in pleural effu nescence assay. Then the rational clinical diagnosis value were established by ROC curves. Results The levels of CEA,CY FRA21 1 and NSE in pleural effusion and serum in cases of lung cancer were significantly higher than those of benign lung diseases(P<0.05). The ratio of CYFRA21 1, serum CYFRA21 1 and CEA levels in pleural fluid and serum(P/S)in the group waft the largest area under the ROC curve. Conclusion Pleural fluid and serum CYFRA21 1 and CEA levels in pleu ral fluid and serum(P/S) is helpful to differentiating benign and malignant pleural effusion diseases. The diagnostic value of pleural fluid CYFRA21 1 is important.
关键词
肺癌/肿瘤标志物/胸腔积液/受试者工作特征曲线Key words
lung cancer/ tumor markers/ pleural effusion/ receiver operating characteristic curve分类
医药卫生引用本文复制引用
冯纾琪,黄钰君,廖春淼,周珍文..用ROC曲线分析胸腔积液和血清肿瘤标志物联合检测对肺癌的诊断价值[J].现代检验医学杂志,2013,28(1):127-129,132,4.
