陕西医学杂志2012，Vol.41Issue(12)：1574-1576,3.
苦参碱诱导宫颈癌Hela细胞的凋亡作用
Effects of matrine on apoptosis hnduction in Cervi Calcarcinoma hela cells
摘要
Abstract
Objective:To study the inhibitory effects of matrine at different concentrations on cervical carcinoma Hela cells in vitro. Methods:Matrine at different concentrations (0. 5,1. 0,1. 5 and 2. 0mg/ml) was re-spectively used to cultivate cervical cancer Hela cells in vitro. After Hela cells were cultivated for 24, 48 and 72 hours respectively, the proliferation of Hela cells treated with matrine was observed by discrepancy microscope; the effect of matrine on cervical cancer cells was assayed by MTT and flowcytometry(FCM). Results: Matrine of differ-ent concentration could significantly inhibit proliferation of Hela cells, and its inhibitory effects increased as the con-centration higher. It was shown that the inhibitory efficacy of matrine in vitro depended on the reaction time and dos-age. The effect on apoptosis rate was also increased. Conclusions: Matrine can significantly inhibit proliferation of cervical carcinoma Hela cells, and induce apoptosis of them.关键词
苦参碱/宫颈癌/Hela细胞/凋亡Key words
Matrine / Cervical cancer / Hela cell / Apoptosis分类
医药卫生引用本文复制引用
王丽,苏宝山,吴静..苦参碱诱导宫颈癌Hela细胞的凋亡作用[J].陕西医学杂志,2012,41(12):1574-1576,3.基金项目
陕西省科技攻关资助项目(No.2004K13-G2) （No.2004K13-G2）
