摘要
Abstract
Objective: To investigate the changes of the levels of plasma brain natriuretic peptide (BNP) in patients with chronic obstructive pulmonary disease (COPD) and chronic cor pulmonale (CCP). Methods: Plasma BNP levels were detected in 30 patients with CCP at acute stage, compared with simple COPD group, and the rela tionship between it and PO2 , pulmonary artery pressure (PAP) was analyzed. Measurements were repeated in the same 30 patients with CCP at remission tage after therapy in hospital. Results: The levels of BNP at acute stage (262. 84 ± 47. 59)pg/ml and remission stage (128. 52 ±24. 82) pg/ml for CCP group were both higher than that in the simple COPD group (64.76 ± 12.03) pg/ml (P<0. 01). Plasma BNP levels were negatively correlated with PO2 (r=-0. 654, P<0. 01) at acute stage, but had no significant correlation at remission stage (P >0. 05). In the acute stage of CCP group, BNP levels in the plasma were positively correlated with the PAP(r=0. 763, P<0. 01). Con clusion: Hypoxia and pulmonary artery hypertension may result in elevation of plasma BNP in patients with COPD accompanied with CCP.BNP may involve in the pathophysiological process of CCP.关键词
肺疾病/慢性阻塞性/病理生理学/利钠肽,脑/代谢Key words
Pulmonary disease/ chronic obstructive/pathophysiology Brain natriuretic peptide/ brain/ metabolism分类
医药卫生
