陕西医学杂志2013，Vol.42Issue(2)：134-136,150,4.
雌激素受体在大鼠肝脏缺血再灌注损伤中的表达及意义
The expression and effects of estrogen receptor in hepatic ischemia reperfusion injury in rats
摘要
Abstract
Objective:To investigate the expressions of estrogen receptor in hepatic ischemia reperfusion injury in rats. Methods : 90 healthy male SD rats were divided into 3 groups randomly: pseudo-operation group(PO) , hepatic ischemia reperfusion group(IR) , estrogen pretreatment plus hepatic ischemia reperfusion group(IRE). Serum ALT and TNF-α levels ; NF-κB and estrogen receptor (ER) expression were measured in time of pre ischemia(T0) , reperfusion l(T1) ,3(T3) , 6 (T6)and 24 hours(T24) respectively. Results : NF-κB,ALT and TNF-α levels in IR and IRE group were increased compared to PO,the values of group IRE were lower than those in group IR. The ER ex-pression of group IR and IRE were increased significantly compared to group PO,but ER expression of IRE group was higher than those in IR group significantly. The liver damage of group IR and IRE were more severe than those in group PO,but the group IR were more severe than those in group IRE. Conclusion: Estrogen pretreatment can sig nificantly increase the estrogen receptor expression , alleviate hepatic ischemia reperfusion injury by decreasing NF-κB and TNF-α level in IR rat medel.关键词
肝脏/缺血再灌注损伤/雌激素/雌激素受体/核转录因子/肿瘤坏死因子Key words
Liver / Ischemia reperfusion injury/ Estrogen/ Estrogen receptor / Nuclear factor / Tumor necrosis factor分类
医药卫生引用本文复制引用
韩新生,胡礼宏,吕建瑞,张蓬勃,王学良..雌激素受体在大鼠肝脏缺血再灌注损伤中的表达及意义[J].陕西医学杂志,2013,42(2):134-136,150,4.基金项目
陕西省卫生厅科研基金项目(02D25)陕西省科技攻关项目(2002K10-G1) （02D25）
