实用妇产科杂志2012，Vol.28Issue(11)：937-941,5.
不同亚型HPV感染情况及与CIN的关系研究
Relationship between Human Papillomavirus Genotypes and Cervical Intraepithelial Neoplasia
摘要
Abstract
Objective:Retrospective analysis of the correlation between different grades of cervcial intraepithelial neoplasia (CIN) and different genotypes of human papillomavirus(HPV). Methods: HPV genotypes were detected in 8640 cases. The association between different grades of CIN and HPV genotypes was analyzed, as well as pathogenicity of different genotypes of HPV. Results:①HPV-positive cases were 1873 (21.7%), including 453 multi-infected cases (5.24%) and 1420 mono-infected cases (16.44%).The detection frequency of HPV is 2417, and the most common genotypes were HPV16 (25.90%), HPV58 (11.92%),HPV52(10.22%),HPV33(6.99%),HPV53(6.54%),HPV18(5.63%). In 372 CIN cases, HPV was detected in 273 cases, and the most common HPV genotypes in CIN group were HPV16 (57. 51 %), HPV18 (16. 48%), HPV58 (13. 92%), HPV52 ( 9.16%), HPV33 (8. 79%), and HPV31 (4. 40%) o②The age of onset of HPV52 is younger, while the pathogenicity of type 52 is weaker. It reveals that the pathgenic machanism of HPV52 is different with other HPV types. ③Compared with HPV16 monoin-fected, HPV18 monoinfected is a weaker pathogenic type to cause cervical intraepithelial neoplasia(P = 0. 003). Compared with HPV58 monoinfected, HPV52 monoinfected is a significant weaker pathogenic type to cause cervical intraepithelial neoplasia(P=0.003). Conclusions:The most common genotypes of HPV in CIN group are 16,18,58,52,33,31. The pathogenicity of type 52 is weaker. The pathogenicity of HPV16 monoinfected is stronger than that of HPV 18 monoinfected, while the pathogenicity of HPV58 monoinfected is stronger than that of HPV 52 monoinfected.关键词
人乳头瘤病毒亚型/宫颈上皮内瘤变/感染率/致病力Key words
HPV genotypes/ Prevalence rate/ Pathogenicity/ Cervcial intraepithelial neoplasia分类
医药卫生引用本文复制引用
项璐璐,洪祖蓓,狄文..不同亚型HPV感染情况及与CIN的关系研究[J].实用妇产科杂志,2012,28(11):937-941,5.基金项目
浦东新区创新基金(编号:PKY2009-Y15) （编号:PKY2009-Y15）
