摘要
Abstract
Objective:To assess the predictive value of a double serum (3-HCG determination combined with its multiple in pregnancy outcome after embryo transfer(ET). Methods;452 IVF-ET cases were enrolled in this analysis and included viable pregnancy group(320 cases), non-viable pregnancy group(32 cases), and biochemical pregnancy group(100 cases). Viable pregnancy included single-pregnancy,twin-pregnancy, and triplet-pregnancy. Non-viable pregnancy included first-trimester miscarriage and ectopic pregnancy. The median of serum p-HCG level on 14 th day and 16 th day following ET and the multiple (HCG 16d:14d) were recorded retrospectively. Results:The HCG14d,HCG16d and HCG16d:14d in viable pregnancy group were all significantly higher than those in non-viable pregnancy group( P=0.000). The cut-off values of HCG14d 、HCG16d and HCG,6d:14d were 380. 59 U/L,807.26 U/l.^2.10, respectively, which were all moderate predictive values. The HCG 14d and HCG 16d in multiple pregnancy group were both higher than those in single pregnancy group(P=0.000),and the cut-off values were 1231.73 U/L and 3053.49 U/L, respectively. The HCG14d、
HCG16dand HCG 16d: 14d in first-trimester miscarriage group were all significantly lower than those in single pregnancy group(P=0.034, P=0. 001 ,P=0.000). The cut-off values were little、moderately, highly predictive value respectively,which the HCG14d,HCG16d and HCG16d:14d were respectively 192.30 U/L,366.46 U/ L,1. 94. The HCG14d,HCG16d and HCG16d14din ectopic pregnancy group were all lower than those in single pregnancy group(P=0. 000,P = 0.000,P = 0. 001) ,and the cut-off values were highly,highly, moderately predictive value respectively, which the HCG14d,HCG16d and HCG16d:14d were respectively 110.36 U/L、 264. 23 U/L、1. 97. Conclusions:The serum (J-HCG quantitative determination on day 14 and day 16 after ET combined with the multiple (HCG16d;14d) might be of some prediction values to pregnancy outcome.关键词
人绒毛膜促性腺激素/体外受精-胚胎移植/倍数/妊娠结局Key words
In vitro fertilization and embryo transfer/ Human chorionic gonadotrophin/ Multiple/ Pregnancy outcome分类
医药卫生
