实用医学杂志2012，Vol.28Issue(10)：1608-1610,3.DOI:10.3969/j.issn.1006-5725.2012.10.011
白介素-4在兔急性肺栓塞并肺损伤的保护机制
The protective mechanism study of anti-inflamation factor IL-4 for pulmonary embolism combined with lung injury
摘要
Abstract
Objective To investigate the protection mechanism of anti-inflamation factor IL-4 for pulmonary embolism combined with lung injury (APTE) in rabbits. Method 30 health New Zealand the rabbits was randomly divided into three groups, each group with 10 rabbits, was used control group (saline) , foreign lower dose IL-4 group and foreign higher dose IL-4 group. ELISA method was use for examination serum IL-4, blood gas analysis and pathology analysis were performed after operation. Results 1. TNF-α and β IL-1 level was obviously decreased in foreign IL-4 intervention group compared with saline control group, 2. TNF-α and β IL-1 level was obviously decreased in high dose foreign IL-4 intervention group compared with lower dose foreign IL-4 intervention group, and it was significant statistically (P < 0.05). Conclusion The foreign IL-4 application decreased the inflamation factor through APTE and had protection function for pulmonary injury.关键词
肺栓塞/肺损伤/抑炎因子Key words
Pulmonary embolism/pulmonary injury/ Anti-inflamation引用本文复制引用
姚艳敏,宋巧凤,王希柱,陈润芝,夏英华..白介素-4在兔急性肺栓塞并肺损伤的保护机制[J].实用医学杂志,2012,28(10):1608-1610,3.基金项目
2011年河北省医学科学研究重点课题计划[编号:唐卫医发2011(77号-20110620) （77号-20110620）
