摘要
Abstract
Objectives The aim of this study is to compare the clinical significanc of phosphorylated insulin-like growth factor-binding protein-1 ( IGFBP-1 ) in cervical secretions of full term pregnancy women, and that of cervical Bishop score in predicting the onset of delivery. Methods A total of 200 pregnant women of 37-41 weeks, with intact fetal membranes were enrolled in this study.The IGFBP-1 was determined by immunochromatography and its successful rate in predicting the onset of delivery within 72 hours was assessed by comparison with cervical Bishop score. Results When the cervix Bishop score was greater than or equal to 7, the positive percentage of IGFBP-1 was 95.12%; and when it was less than 7, the positive percentage of IGFBP-1 was 49.69%, the difference was significant (P< 0.001). As cervix maturity degree increased, the positive percentage of IGFBP-1 was rising gradually. There was a significant positive correlation between the cervix maturity and the positive rate of IGFBP-1. Among 110 cases of the onset of delivery within 72 hours, there were 108 cases (98.18%) positive for IGFBP-1, while 2 cases (1.82%) were negative for IGFBP-1. Among 90 cases of the onset of delivery more than 72 hours, there were 10 cases (11.11%) positive for IGFBP-1, while 80 cases (88.89%) were negative for IGFBP-1, the difference was significant (P < 0.001). Within 72 hours before the onset of delivery, the sensitivity, specificity, positive predictive value and negative predictive value of IGFBP-1 were 98.18%, 88.89%, 91.53% and 97.56%, respectively, While, these values of the Bishop score were 31.82%, 93.33%, 85.37%, 52.83%. Conclusions IGFBP-1 reflects cervical maturation, and it can serve as an objective indicator for predicting the onset of delivery. Determining IGFBP-1 is obviously better than using cervical Bishop score in predicting the onset of delivery, and the positive IGFBP-1 could predict the onset of delivery within 72 hours.关键词
胰岛素样生长因子结合蛋白1/宫颈评分/预测Key words
Insulin-like grouth factor binding protein 1/ Cervical Bishop score/ Prediction
